A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Proteins containing the UBA domain are able to bind to multi-ubiquitin chains.

Wilkinson CR, Seeger M, Hartmann-Petersen R, Stone M, Wallace M, Semple C, Gordon C

The UBA domain is a motif found in a variety of proteins, some of which are associated with the ubiquitin-proteasome system. We describe the isolation of a fission-yeast gene, mud1+, which encodes a UBA domain containing protein that is able to bind multi-ubiquitin chains. We show that the UBA domain is responsible for this activity. Two other proteins containing this ... [more]

Nat. Cell Biol. Oct. 01, 2001; 3(10);939-43 [Pubmed: 11584278]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Curated By

BioGRID

Interaction Summary

DPH1

Gene Ontology Biological Process

Gene Ontology Molecular Function

polyubiquitin binding [IDA]

Gene Ontology Cellular Component

RPN10