A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Roles of a fimbrin and an alpha-actinin-like protein in fission yeast cell polarization and cytokinesis.

Wu JQ, Baehler J, Pringle JR

Eukaryotic cells contain many actin-interacting proteins, including the alpha-actinins and the fimbrins, both of which have actin cross-linking activity in vitro. We report here the identification and characterization of both an alpha-actinin-like protein (Ain1p) and a fimbrin (Fim1p) in the fission yeast Schizosaccharomyces pombe. Ain1p localizes to the actomyosin-containing medial ring in an F-actin-dependent manner, and the Ain1p ring contracts ... [more]

Mol. Biol. Cell Apr. 01, 2001; 12(4);1061-77 [Pubmed: 11294907]

Throughput

Low Throughput

Ontology Terms

phenotype: cold sensitivity (APO:0000148)
phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
AIN1 ACT1	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Li Y (2016)	Low	-	BioGRID	-
AIN1 ACT1	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Morita R (2017)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

AIN1

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding, bridging [TAS]

Gene Ontology Cellular Component

ACT1