A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Bypass of the requirement for cdc16p GAP function in Schizosaccharomyces pombe by mutation of the septation initiation network genes.

Fournier N, Cerutti L, Beltraminelli N, Salimova E, Simanis V

The onset of septum formation in the fission yeast Schizosaccharomyces pombe is signaled via the spglp GTPase-switch, which is part of the septation initiation network. This is negatively regulated by the two-component GTPase-activating protein (GAP) comprised of the products of the cdc16 and byr4 genes. Loss-of-function mutations in either of these genes result in multiple rounds of septum formation without ... [more]

Arch. Microbiol. Jan. 01, 2001; 175(1);62-9 [Pubmed: 11271422]

Throughput

Low Throughput

Ontology Terms

phenotype: cold sensitivity (APO:0000148)
phenotype: vegetative growth (APO:0000106)

Additional Notes

mutation rescues the lethality of a cdc16 mutant at low temperatures

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CDC16 CDC7	Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.	Cullen CF (2000)	Low	-	BioGRID	672265
CDC16 CDC7	Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Jwa M (1998)	Low	-	BioGRID	246409
CDC7 CDC16	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Marks J (1992)	Low	-	BioGRID	300764
CDC7 CDC16	Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.	Cullen CF (2000)	Low	-	BioGRID	672261
CDC16 CDC7	Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.	Cullen CF (2000)	Low	-	BioGRID	672262

Curated By

BioGRID

Interaction Summary

CDC16

Gene Ontology Biological Process

Gene Ontology Molecular Function

GTPase activator activity [IGI]protein binding [IPI]

Gene Ontology Cellular Component

CDC7