BAIT

RAE1

cut21, SPBC16A3.05c
RNA export factor, nucleoporin Rae1
Schizosaccharomyces pombe (972h)
PREY

NUP184

SPAP27G11.10c
nucleoporin Nup184
GO Process (3)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Mex67p of Schizosaccharomyces pombe interacts with Rae1p in mediating mRNA export.

Yoon JH, Love DC, Guhathakurta A, Hanover JA, Dhar R

We identified the Schizosaccharomyces pombe mex67 gene (spmex67) as a multicopy suppressor of rae1-167 nup184-1 synthetic lethality and the rae1-167 ts mutation. spMex67p, a 596-amino-acid-long protein, has considerable sequence similarity to the Saccharomyces cerevisiae Mex67p (scMex67p) and human Tap. In contrast to scMEX67, spmex67 is essential for neither growth nor nuclear export of mRNA. However, an spmex67 null mutation (Deltamex67) ... [more]

Mol. Cell. Biol. Dec. 01, 2000; 20(23);8767-82 [Pubmed: 11073978]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
RAE1 NUP184
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
247572
NUP184 RAE1
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
448953

Curated By

  • BioGRID