A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Crp79p, like Mex67p, is an auxiliary mRNA export factor in Schizosaccharomyces pombe.

Thakurta AG, Whalen WA, Yoon JH, Bharathi A, Kozak L, Whiteford C, Love DC, Hanover JA, Dhar R

The export of mRNA from the nucleus to the cytoplasm involves interactions of proteins with mRNA and the nuclear pore complex. We isolated Crp79p, a novel mRNA export factor from the same synthetic lethal screen that led to the identification of spMex67p in Schizosaccharomyces pombe. Crp79p is a 710-amino-acid-long protein that contains three RNA recognition motif domains in tandem and ... [more]

Mol. Biol. Cell Aug. 01, 2002; 13(8);2571-84 [Pubmed: 12181330]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
NUP184 RAE1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Whalen WA (1999)	Low	-	BioGRID	448953
RAE1 NUP184	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Yoon JH (2000)	Low	-	BioGRID	247404

Curated By

BioGRID

Interaction Summary

RAE1

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

NUP184