BAIT
AMS2
SPCC4F11.01, SPCC290.04
cell cycle regulated GATA-type transcription factor Ams2
GO Process (6)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- CENP-A containing nucleosome assembly [IMP]
- cellular protein localization [IMP]
- mitotic sister chromatid segregation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein localization to chromosome, centromeric region [IMP]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [NAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- centromeric DNA binding [IDA]
- core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [NAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- centromeric DNA binding [IDA]
- core promoter proximal region sequence-specific DNA binding [IMP]
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
MIS6
SPAC1687.20c
inner centromere protein, CENP-I ortholog Mis6
GO Process (4)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A cell cycle-regulated GATA factor promotes centromeric localization of CENP-A in fission yeast.
CENP-A, the centromere-specific histone H3 variant, plays a crucial role in organizing kinetochore chromatin for precise chromosome segregation. We have isolated Ams2, a Daxx-like motif-containing GATA factor, and histone H4, as multicopy suppressors of cnp1-1, an S. pombe CENP-A mutant. While depletion of Ams2 results in the reduction of CENP-A binding to the centromere and chromosome missegregation, increasing its dosage ... [more]
Mol. Cell Jan. 01, 2003; 11(1);175-87 [Pubmed: 12535531]
Throughput
- Low Throughput
Ontology Terms
- phenotype: heat sensitivity (APO:0000147)
- phenotype: inviable (APO:0000112)
Additional Notes
- at 30 degrees
Curated By
- BioGRID