BAIT

YAM8

ehs1, SPAC1F5.08c
stretch-activated calcium channel Yam8
GO Process (4)
GO Function (1)
GO Component (4)
Schizosaccharomyces pombe (972h)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Schizosaccharomyces pombe ehs1p is involved in maintaining cell wall integrity and in calcium uptake.

Carnero E, Ribas JC, Garcia B, Duran A, Sanchez Y

The Schizosaccharomyces pombe mutant ehs1-1 mutant was isolated on the basis of its hypersensitivity to Echinocandin and Calcofluor White, which inhibit cell wall synthesis. The mutant shows a thermosensitive growth phenotype that is suppressed in the presence of an osmotic stabiliser. The mutant also showed other cell wall-associated phenotypes, such as enhanced sensitivity to enzymatic cell wall degradation and an ... [more]

Mol. Gen. Genet. Sep. 01, 2000; 264(1);173-83 [Pubmed: 11016847]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: heat sensitivity (APO:0000147)
  • phenotype: mating efficiency (APO:0000034)
  • phenotype: vegetative growth (APO:0000106)
  • phenotype: cell shape (APO:0000051)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
YAM8 PCK2
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
796696
PCK2 YAM8
Synthetic Rescue
Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Low-BioGRID
796697

Curated By

  • BioGRID