A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Schizosaccharomyces pombe ehs1p is involved in maintaining cell wall integrity and in calcium uptake.

Carnero E, Ribas JC, Garcia B, Duran A, Sanchez Y

The Schizosaccharomyces pombe mutant ehs1-1 mutant was isolated on the basis of its hypersensitivity to Echinocandin and Calcofluor White, which inhibit cell wall synthesis. The mutant shows a thermosensitive growth phenotype that is suppressed in the presence of an osmotic stabiliser. The mutant also showed other cell wall-associated phenotypes, such as enhanced sensitivity to enzymatic cell wall degradation and an ... [more]

Mol. Gen. Genet. Sep. 01, 2000; 264(1);173-83 [Pubmed: 11016847]

Throughput

Low Throughput

Ontology Terms

phenotype: cell shape (APO:0000051)
phenotype: vegetative growth (APO:0000106)

Additional Notes

deletion of ehs1 rescues lethality and cell growth defects associated with pck2 overexpression

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
YAM8 PCK2	Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.	Carnero E (2000)	Low	-	BioGRID	247771
YAM8 PCK2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Carnero E (2000)	Low	-	BioGRID	796696

Curated By

BioGRID

Interaction Summary

PCK2

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

YAM8