DNA polymerase epsilon subunit Dpb4
GO Process (1)
GO Function (0)
GO Component (4)

Gene Ontology Biological Process

Schizosaccharomyces pombe (972h)


pol2, SPBC25H2.13c
DNA polymerase epsilon catalytic subunit Pol2
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Identification and cloning of two putative subunits of DNA polymerase epsilon in fission yeast.

Spiga MG, D'Urso G

DNA polymerase epsilon (Pol epsilon) is a multi-subunit enzyme required for the initiation of chromosomal DNA replication. Here, we report the cloning of two fission yeast genes, called dpb3+ and dpb4+ that encode proteins homologous to the two smallest subunits of Pol epsilon. Although Dpb4 is not required for cell viability, Deltadpb4 mutants are synthetically lethal with mutations in four ... [more]

Nucleic Acids Res. Sep. 25, 2004; 32(16);4945-53 [Pubmed: 15388803]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.


Curated By

  • BioGRID