A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Hsp90 protein in fission yeast Swo1p and UCS protein Rng3p facilitate myosin II assembly and function.

Mishra M, D'souza VM, Chang KC, Huang Y, Balasubramanian MK

The F-actin-based molecular motor myosin II is involved in a variety of cellular processes such as muscle contraction, cell motility, and cytokinesis. In recent years, a family of myosin II-specific cochaperones of the UCS family has been identified from work with yeasts, fungi, worms, and humans. Biochemical analyses have shown that a complex of Hsp90 and the Caenorhabditis elegans UCS ... [more]

Eukaryotic Cell Mar. 01, 2005; 4(3);567-76 [Pubmed: 15755919]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
RNG3 HSP90	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Mishra M (2005)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

HSP90

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATP binding [IDA]ATPase activity [IDA]ATPase activity, coupled [ISO]protein binding [IPI]protein binding involved in protein folding [EXP]unfolded protein binding [IDA]

Gene Ontology Cellular Component

RNG3

Gene Ontology Biological Process

Gene Ontology Molecular Function

myosin binding [ISO]protein binding [IPI]