A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Cdc48 is required for the stability of Cut1/separase in mitotic anaphase.

Ikai N, Yanagida M

Separase, a large protease essential for sister chromatid separation, cleaves the cohesin subunit Scc1/Rad21 during anaphase and leads to dissociation of the link between sister chromatids. Securin, a chaperone and inhibitor of separase, is ubiquitinated by APC/cyclosome, and degraded by 26S proteasome in anaphase. Cdc48/VCP/p97, an AAA ATPase, is involved in a variety of cellular activities, many of which are ... [more]

J. Struct. Biol. Oct. 01, 2006; 156(1);50-61 [Pubmed: 16904908]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CDC48 CUT2	Dosage Lethality Dosage Lethality A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.	Ikai N (2006)	Low	-	BioGRID	436285
CDC48 CUT2	Dosage Lethality Dosage Lethality A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.	Yuasa T (2004)	Low	-	BioGRID	247883

Curated By

BioGRID

Interaction Summary

CDC48

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATPase activity [NAS]protein binding [IPI]

Gene Ontology Cellular Component

CUT2