sec19, SPAC22H10.12c
GDP dissociation inhibitor Gdi1 (predicted)
GO Process (3)
GO Function (1)
GO Component (3)
Schizosaccharomyces pombe (972h)


sec14, SPAC3H8.10
sec14 cytosolic factor family Sec14
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Genetic evidence for phospholipid-mediated regulation of the Rab GDP-dissociation inhibitor in fission yeast.

Ma Y, Kuno T, Kita A, Nabata T, Uno S, Sugiura R

We have previously identified mutant alleles of genes encoding two Rab proteins, Ypt3 and Ryh1, through a genetic screen using the immunosuppressant drug FK506 in fission yeast. In the same screen, we isolated gdi1-i11, a mutant allele of the essential gdi1+ gene encoding Rab GDP-dissociation inhibitor. In gdi1-i11, a conserved Gly267 was substituted by Asp. The Gdi1G267D protein failed to ... [more]

Genetics Nov. 01, 2006; 174(3);1259-71 [Pubmed: 16980382]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
Dosage Rescue
Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.


Curated By

  • BioGRID