BAIT
C9ORF72
ALSFTD, FTDALS
chromosome 9 open reading frame 72
GO Process (2)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SETX
A130090N03, A930037J23Rik, AOA2, AW060766, Als4, SCAR1, Sen1, mKIAA0625, RP23-426D2.7
senataxin
GO Process (19)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- MAPK cascade [ISO]
- cellular response to DNA damage stimulus [ISO]
- cellular response to fibroblast growth factor stimulus [ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to oxidative stress [ISO]
- cellular response to retinoic acid [ISO]
- circadian rhythm [IMP]
- double-strand break repair [ISO]
- fibroblast growth factor receptor signaling pathway [ISO]
- mRNA splice site selection [ISO]
- negative regulation of apoptotic process [ISO]
- positive regulation of DNA-templated transcription, initiation [ISO]
- positive regulation of DNA-templated transcription, termination [ISO]
- positive regulation of RNA splicing [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein kinase B signaling [ISO]
- termination of RNA polymerase II transcription [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.
An intronic expansion of GGGGCC repeats within the C9ORF72 gene is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). Ataxin-2 with intermediate length of polyglutamine expansions (Ataxin-2 Q30x) is a genetic modifier of the disease. Here, we found that C9ORF72 forms a complex with the WDR41 and SMCR8 proteins to act as a GDP/GTP exchange ... [more]
EMBO J. Dec. 15, 2015; 35(12);1276-97 [Pubmed: 27103069]
Throughput
- Low Throughput
Curated By
- BioGRID