BAIT
C9ORF72
ALSFTD, FTDALS
chromosome 9 open reading frame 72
GO Process (2)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
VPS4B
8030489C12Rik, Skd1
vacuolar protein sorting 4b (yeast)
GO Process (16)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- cholesterol transport [IMP]
- endosomal transport [ISO]
- endosome organization [IMP]
- endosome to lysosome transport via multivesicular body sorting pathway [ISO]
- intracellular cholesterol transport [ISO]
- negative regulation of exosomal secretion [ISO]
- positive regulation of exosomal secretion [ISO]
- positive regulation of viral release from host cell [ISO]
- potassium ion transport [IDA]
- regulation of viral process [ISO]
- response to lipid [ISO]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ISO]
- ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [ISO]
- vacuole organization [IBA]
- viral budding via host ESCRT complex [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.
An intronic expansion of GGGGCC repeats within the C9ORF72 gene is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). Ataxin-2 with intermediate length of polyglutamine expansions (Ataxin-2 Q30x) is a genetic modifier of the disease. Here, we found that C9ORF72 forms a complex with the WDR41 and SMCR8 proteins to act as a GDP/GTP exchange ... [more]
EMBO J. Dec. 15, 2015; 35(12);1276-97 [Pubmed: 27103069]
Throughput
- Low Throughput
Curated By
- BioGRID