BAIT
PRPF8
HPRP8, PRP8, PRPC8, RP13, SNRNP220
pre-mRNA processing factor 8
GO Process (6)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DPM1
CDGIE, MPDS, RP5-914P20.2
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
GO Process (9)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- C-terminal protein lipidation [TAS]
- GPI anchor biosynthetic process [IDA]
- cellular protein metabolic process [TAS]
- dolichol metabolic process [IDA]
- dolichol-linked oligosaccharide biosynthetic process [TAS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein O-linked mannosylation [IDA]
- protein mannosylation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.
Splicing is catalyzed by the spliceosome, a complex of five major small nuclear ribonucleoprotein particles (snRNPs). The pre-mRNA splicing factor PRPF8 is a crucial component of the U5 snRNP, and together with EFTUD2 and SNRNP200, it forms a central module of the spliceosome. Using quantitative proteomics, we identified assembly intermediates containing PRPF8, EFTUD2, and SNRNP200 in association with the HSP90/R2TP ... [more]
J. Cell Biol. Dec. 05, 2016; 216(6);1579-1596 [Pubmed: 28515276]
Throughput
- High Throughput
Curated By
- BioGRID