BAIT
EFTUD2
MFDGA, MFDM, SNRNP116, Snrp116, Snu114, U5-116KD
elongation factor Tu GTP binding domain containing 2
GO Process (5)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
WNT11
HWNT11
wingless-type MMTV integration site family, member 11
GO Process (27)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- adrenal gland development [IEP]
- cell fate commitment [IBA]
- cellular response to retinoic acid [ISS]
- cloacal septation [IEP]
- embryonic skeletal system development [IEP]
- lung-associated mesenchyme development [IEP]
- mesonephric duct development [IEP]
- negative regulation of apoptotic process [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of cartilage development [NAS]
- negative regulation of cell death [IMP]
- negative regulation of cell growth [IMP]
- negative regulation of cell migration [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- neuroendocrine cell differentiation [IMP]
- neuron differentiation [IBA, ISS]
- palate development [IMP]
- positive regulation of Ras GTPase activity [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of protein kinase C signaling [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of stress fiber assembly [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- protein localization to cell surface [IMP]
- protein phosphorylation [IMP]
- ureteric bud morphogenesis [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.
Splicing is catalyzed by the spliceosome, a complex of five major small nuclear ribonucleoprotein particles (snRNPs). The pre-mRNA splicing factor PRPF8 is a crucial component of the U5 snRNP, and together with EFTUD2 and SNRNP200, it forms a central module of the spliceosome. Using quantitative proteomics, we identified assembly intermediates containing PRPF8, EFTUD2, and SNRNP200 in association with the HSP90/R2TP ... [more]
J. Cell Biol. Dec. 05, 2016; 216(6);1579-1596 [Pubmed: 28515276]
Throughput
- High Throughput
Additional Notes
- Eftud2-DADE
Curated By
- BioGRID