BAIT
EFTUD2
MFDGA, MFDM, SNRNP116, Snrp116, Snu114, U5-116KD
elongation factor Tu GTP binding domain containing 2
GO Process (5)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MACF1
ABP620, ACF7, MACF, OFC4
microtubule-actin crosslinking factor 1
GO Process (8)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [ISS]
- Golgi to plasma membrane protein transport [IDA]
- positive regulation of Wnt signaling pathway [ISS]
- positive regulation of axon extension [IDA]
- regulation of epithelial cell migration [ISS]
- regulation of focal adhesion assembly [ISS]
- regulation of microtubule-based process [IMP]
- wound healing [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.
Splicing is catalyzed by the spliceosome, a complex of five major small nuclear ribonucleoprotein particles (snRNPs). The pre-mRNA splicing factor PRPF8 is a crucial component of the U5 snRNP, and together with EFTUD2 and SNRNP200, it forms a central module of the spliceosome. Using quantitative proteomics, we identified assembly intermediates containing PRPF8, EFTUD2, and SNRNP200 in association with the HSP90/R2TP ... [more]
J. Cell Biol. Dec. 05, 2016; 216(6);1579-1596 [Pubmed: 28515276]
Throughput
- High Throughput
Additional Notes
- Eftud2-DADE
Curated By
- BioGRID