BAIT

PPP5C

PP5, PPP5, PPT
protein phosphatase 5, catalytic subunit
Alzheimer's Disease Project
Cell Cycle - Mitotic Spindle Assembly Project
Homo sapiens
PREY

VIM

CTRCT30, HEL113, RP11-124N14.1
vimentin
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer.

Dushukyan N, Dunn DM, Sager RA, Woodford MR, Loiselle DR, Daneshvar M, Baker-Williams AJ, Chisholm JD, Truman AW, Vaughan CK, Haystead TA, Bratslavsky G, Bourboulia D, Mollapour M

The serine/threonine protein phosphatase 5 (PP5) regulates multiple cellular signaling networks. A number of cellular factors, including heat shock protein 90 (Hsp90), promote the activation of PP5. However, it is unclear whether post-translational modifications also influence PP5 phosphatase activity. Here, we show an "on/off switch" mechanism for PP5 regulation. The casein kinase 1δ (CK1δ) phosphorylates T362 in the catalytic domain ... [more]

Cell Rep Nov. 14, 2017; 21(7);1883-1895 [Pubmed: 29141220]

Throughput

  • High Throughput

Curated By

  • BioGRID