TNIP2
Gene Ontology Biological Process
- CD40 signaling pathway [ISS]
- cellular response to lipopolysaccharide [ISS]
- interleukin-1-mediated signaling pathway [ISS]
- negative regulation of endothelial cell apoptotic process [IDA]
- positive regulation of B cell activation [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of macrophage activation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein stabilization [ISS]
- toll-like receptor 2 signaling pathway [ISS]
- toll-like receptor 3 signaling pathway [ISS]
- toll-like receptor 9 signaling pathway [ISS]
Gene Ontology Molecular Function
TSG101
Gene Ontology Biological Process
- endosomal transport [TAS]
- intracellular transport of virus [TAS]
- membrane organization [TAS]
- positive regulation of exosomal secretion [IMP]
- regulation of extracellular vesicular exosome assembly [IMP]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IC, IDA, IMP]
- viral budding [IMP, ISS]
- viral life cycle [TAS]
- viral process [TAS]
- viral protein processing [TAS]
- virion assembly [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.
The NF-κB family of transcription factors is pivotal in controlling cellular responses to environmental stresses; abnormal nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling features in many autoimmune diseases and cancers. Several components of the NF-κB signaling pathway have been reported to interact with the protein TNIP2 (also known as ABIN2), and TNIP2 can both positively and negatively regulate ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TNIP2 TSG101 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| TNIP2 TSG101 | FRET FRET An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID