BAIT
TNIP2
ABIN2, FLIP1, KLIP, RP3-474M20.1
TNFAIP3 interacting protein 2
GO Process (12)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- CD40 signaling pathway [ISS]
- cellular response to lipopolysaccharide [ISS]
- interleukin-1-mediated signaling pathway [ISS]
- negative regulation of endothelial cell apoptotic process [IDA]
- positive regulation of B cell activation [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of macrophage activation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein stabilization [ISS]
- toll-like receptor 2 signaling pathway [ISS]
- toll-like receptor 3 signaling pathway [ISS]
- toll-like receptor 9 signaling pathway [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
DNAJA1
DJ-2, DjA1, HDJ2, HSDJ, HSJ2, HSPF4, NEDD7, hDJ-2, RP11-54K16.1
DnaJ (Hsp40) homolog, subfamily A, member 1
GO Process (9)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- negative regulation of JUN kinase activity [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein ubiquitination [IDA]
- positive regulation of apoptotic process [IMP]
- protein folding [TAS]
- protein localization to mitochondrion [IMP]
- protein refolding [IBA]
- regulation of protein transport [IDA]
- response to unfolded protein [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.
The NF-κB family of transcription factors is pivotal in controlling cellular responses to environmental stresses; abnormal nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling features in many autoimmune diseases and cancers. Several components of the NF-κB signaling pathway have been reported to interact with the protein TNIP2 (also known as ABIN2), and TNIP2 can both positively and negatively regulate ... [more]
Mol. Cell Proteomics Dec. 01, 2015; 15(11);3435-3449 [Pubmed: 27609421]
Throughput
- High Throughput
Curated By
- BioGRID