BAIT

CHD3

Mi-2a, Mi2-ALPHA, ZFH

chromodomain helicase DNA binding protein 3

GO Process (5)

GO Function (5)

GO Component (6)

Gene Ontology Biological Process

DNA duplex unwinding [TAS]

centrosome organization [IDA]

regulation of transcription from RNA polymerase II promoter [TAS]

regulation of transcription, DNA-templated [NAS]

spindle organization [IDA]

Gene Ontology Molecular Function

ATP-dependent DNA helicase activity [TAS]
helicase activity [NAS]
poly(A) RNA binding [IDA]
protein binding [IPI]
zinc ion binding [NAS]

Gene Ontology Cellular Component

NuRD complex [IDA]

centrosome [IDA]

cytoplasm [IDA]

intermediate filament cytoskeleton [IDA]

nucleolus [IDA]

nucleus [IDA, NAS]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

HSP90AA1

EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2

heat shock protein 90kDa alpha (cytosolic), class A member 1

Alzheimer's Disease Project

Arachidonic Acid Pathway Project

GO Process (16)

GO Function (10)

GO Component (10)

Gene Ontology Molecular Function

ATP binding [TAS]
ATPase activity [IDA]
MHC class II protein complex binding [IDA]
TPR domain binding [IDA, TAS]
identical protein binding [IPI]
nitric-oxide synthase regulator activity [IDA]
nucleotide binding [TAS]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein homodimerization activity [TAS]

Gene Ontology Cellular Component

cytoplasm [IDA]

cytosol [NAS, TAS]

endocytic vesicle lumen [TAS]

extracellular region [TAS]

extracellular vesicular exosome [IDA]

mitochondrion [IDA]

nucleoplasm [IDA]

plasma membrane [TAS]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

Hoffmeister H, Fuchs A, Erdel F, Pinz S, Groebner-Ferreira R, Bruckmann A, Deutzmann R, Schwartz U, Maldonado R, Huber C, Dendorfer AS, Rippe K, Laengst G

CHD3 and CHD4 (Chromodomain Helicase DNA binding protein), two highly similar representatives of the Mi-2 subfamily of SF2 helicases, are coexpressed in many cell lines and tissues and have been reported to act as the motor subunit of the NuRD complex (nucleosome remodeling and deacetylase activities). Besides CHD proteins, NuRD contains several repressors like HDAC1/2, MTA2/3 and MBD2/3, arguing for ... [more]

Nucleic Acids Res. Oct. 13, 2017; 45(18);10534-10554 [Pubmed: 28977666]

Throughput

High Throughput

Curated By

BioGRID