BAIT
LCK
IMD22, LSK, YT16, p56lck, pp58lck, RP4-675E8.4
LCK proto-oncogene, Src family tyrosine kinase
GO Process (30)
GO Function (14)
GO Component (7)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IBA]
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- T cell differentiation [IMP, ISS]
- T cell receptor signaling pathway [TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISS]
- blood coagulation [TAS]
- cellular response to peptide hormone stimulus [IBA]
- cellular zinc ion homeostasis [IEP, ISS]
- dephosphorylation [IDA, ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- hemopoiesis [NAS]
- innate immune response [IBA, TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- positive regulation of T cell activation [IDA, ISS]
- positive regulation of T cell receptor signaling pathway [NAS]
- positive regulation of intrinsic apoptotic signaling pathway [IMP, ISS]
- protein phosphorylation [IDA]
- regulation of cell proliferation [IBA]
- regulation of defense response to virus by virus [TAS]
- regulation of lymphocyte activation [NAS]
- release of sequestered calcium ion into cytosol [ISS]
- response to drug [IDA, ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- viral process [TAS]
Gene Ontology Molecular Function- ATPase binding [IPI]
- CD4 receptor binding [IPI]
- CD8 receptor binding [IPI]
- SH2 domain binding [IPI, ISS]
- glycoprotein binding [IPI]
- identical protein binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- protein serine/threonine phosphatase activity [IDA, ISS]
- protein tyrosine kinase activity [EXP, IDA, ISS, TAS]
- ATPase binding [IPI]
- CD4 receptor binding [IPI]
- CD8 receptor binding [IPI]
- SH2 domain binding [IPI, ISS]
- glycoprotein binding [IPI]
- identical protein binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- protein serine/threonine phosphatase activity [IDA, ISS]
- protein tyrosine kinase activity [EXP, IDA, ISS, TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
GATA3
HDR, HDRS
GATA binding protein 3
GO Process (58)
GO Function (13)
GO Component (4)
Gene Ontology Biological Process
- T cell receptor signaling pathway [ISS]
- TOR signaling [ISS]
- anatomical structure formation involved in morphogenesis [ISS]
- anatomical structure morphogenesis [TAS]
- aortic valve morphogenesis [ISS]
- blood coagulation [TAS]
- canonical Wnt signaling pathway involved in metanephric kidney development [ISS]
- cardiac right ventricle morphogenesis [ISS]
- cell fate determination [ISS]
- cellular response to interferon-alpha [IEP]
- cellular response to interleukin-4 [IEP]
- cellular response to tumor necrosis factor [IEP]
- defense response [TAS]
- ear development [IMP]
- kidney development [IMP]
- lymphocyte migration [IDA]
- male gonad development [ISS]
- mesenchymal to epithelial transition [IDA]
- mesonephros development [ISS]
- negative regulation of cell cycle [IMP]
- negative regulation of cell motility [IMP]
- negative regulation of cell proliferation [ISS]
- negative regulation of cell proliferation involved in mesonephros development [ISS]
- negative regulation of endothelial cell apoptotic process [IMP]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation [ISS]
- negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation [ISS]
- negative regulation of inflammatory response [IMP]
- negative regulation of mammary gland epithelial cell proliferation [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- nephric duct formation [ISS]
- nephric duct morphogenesis [ISS]
- norepinephrine biosynthetic process [ISS]
- pharyngeal system development [ISS]
- phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of T cell differentiation [ISS]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of interleukin-13 secretion [IDA, IMP]
- positive regulation of interleukin-4 production [ISS]
- positive regulation of interleukin-5 secretion [IDA]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of signal transduction [IMP]
- positive regulation of thyroid hormone generation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISS]
- positive regulation of transcription regulatory region DNA binding [IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISS]
- positive regulation of ureteric bud formation [ISS]
- regulation of cellular response to X-ray [IMP]
- regulation of cytokine biosynthetic process [ISS]
- regulation of nephron tubule epithelial cell differentiation [ISS]
- response to estrogen [IEP]
- response to virus [IEP]
- signal transduction [ISS]
- sympathetic nervous system development [ISS]
- transcription from RNA polymerase II promoter [TAS]
- ureteric bud formation [ISS]
- uterus development [ISS]
- ventricular septum development [ISS]
Gene Ontology Molecular Function- DNA binding [TAS]
- E-box binding [IDA]
- HMG box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IMP]
- core promoter proximal region sequence-specific DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- nucleic acid binding transcription factor activity [IDA, IMP]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- DNA binding [TAS]
- E-box binding [IDA]
- HMG box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IMP]
- core promoter proximal region sequence-specific DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- nucleic acid binding transcription factor activity [IDA, IMP]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
While alternative splicing is known to diversify the functional characteristics of some genes, the extent to which protein isoforms globally contribute to functional complexity on a proteomic scale remains unknown. To address this systematically, we cloned full-length open reading frames of alternatively spliced transcripts for a large number of human genes and used protein-protein interaction profiling to functionally compare hundreds ... [more]
Cell Feb. 11, 2016; 164(4);805-17 [Pubmed: 26871637]
Throughput
- High Throughput
Curated By
- BioGRID