TRAF3
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of type I interferon production [TAS]
- regulation of cytokine production [ISS]
- regulation of defense response to virus [ISS]
- regulation of interferon-beta production [ISS]
- regulation of proteolysis [IMP]
- signal transduction [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [ISS, TAS]
- tumor necrosis factor-mediated signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
USP17L2
Gene Ontology Biological Process
- CAAX-box protein processing [IMP]
- cell cycle checkpoint [IMP]
- mitotic cell cycle checkpoint [IMP]
- negative regulation of Ras GTPase activity [IDA]
- negative regulation of histone deacetylation [IMP]
- negative regulation of protein processing [IMP]
- negative regulation of protein targeting to membrane [IMP]
- positive regulation of MDA-5 signaling pathway [IMP]
- positive regulation of RIG-I signaling pathway [IMP]
- positive regulation of Rho GTPase activity [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein K48-linked deubiquitination [IMP]
- protein K63-linked deubiquitination [IDA, IMP]
- protein deubiquitination [IDA]
- regulation of apoptotic process [IMP]
- regulation of cell migration [IMP]
- regulation of cell proliferation [IMP]
- regulation of defense response to virus by host [IMP]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of ruffle assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation.
Macrophage accumulation and inflammation in the lung owing to stresses and diseases is a cause of lung cancer development. However, molecular mechanisms underlying the interaction between macrophages and cancer cells, which drive inflammation and stemness in cancers, are poorly understood. In this study, we investigated the expression of ubiquitin-specific peptidase 17 (USP17) in lung cancers, and role of elevated USP17 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| USP17L2 TRAF3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID