Publication

Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes.

Martinez-Noel G, Luck K, Kuehnle S, Desbuleux A, Szajner P, Galligan JT, Rodriguez D, Zheng L, Boyland K, Leclere F, Zhong Q, Hill DE, Vidal M, Howley PM

Perturbations in activity and dosage of the UBE3A ubiquitin-ligase have been linked to Angelman syndrome and autism spectrum disorders. UBE3A was initially identified as the cellular protein hijacked by the human papillomavirus E6 protein to mediate the ubiquitylation of p53, a function critical to the oncogenic potential of these viruses. Although a number of substrates have been identified, the normal ... [more]

Throughput

• High Throughput

Ontology Terms

• phenotype: sh-sy5y cell (BTO:0000793)

Additional Notes

• High-confidence candidate-interacting proteins (HCIPs) for wild type UBE3A/E6AP had NWD scores equal to or higher than 1 (CompPASS method).
• UBE3A/E6AP interactor in SH-SY5Y cells detected as HCIP in more than one immunoprecipitation.

Curated By

• BioGRID