AGTR2
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IC]
- G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [ISS]
- angiotensin-activated signaling pathway [IPI, TAS]
- blood vessel remodeling [TAS]
- brain development [NAS]
- cell surface receptor signaling pathway [IDA]
- extracellular negative regulation of signal transduction [TAS]
- intracellular signal transduction [ISS]
- negative regulation of blood vessel endothelial cell migration [NAS]
- negative regulation of cell growth [TAS]
- negative regulation of heart rate [ISS]
- negative regulation of neurotrophin TRK receptor signaling pathway [IMP]
- nitric oxide mediated signal transduction [IC, TAS]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of nitric oxide biosynthetic process [IC]
- positive regulation of nitric-oxide synthase activity [ISS]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of vasodilation [IDA]
- regulation of blood pressure [TAS]
- regulation of systemic arterial blood pressure by circulatory renin-angiotensin [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MTUS1
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP.
Negative regulation of mitogenic pathways is a fundamental process that remains poorly characterized. The angiotensin II AT2 receptor is a rare example of a 7-transmembrane domain receptor that negatively cross-talks with receptor tyrosine kinases to inhibit cell growth. In the present study, we report the molecular cloning of a novel protein, ATIP1 (AT2-interacting protein), which interacts with the C-terminal tail ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AGTR2 MTUS1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID