CDC25
Gene Ontology Biological Process
- mitotic DNA replication checkpoint [IMP]
- peptidyl-tyrosine dephosphorylation involved in activation of protein kinase activity [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle [IMP]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cell size [NAS]
- signal transduction involved in intra-S DNA damage checkpoint [IMP]
Gene Ontology Molecular Function
STY1
Gene Ontology Biological Process
- G1 cell cycle arrest in response to nitrogen starvation [IMP]
- G1 to G0 transition [IMP]
- MAPK cascade in response to starvation [IMP]
- MAPK cascade involved in osmosensory signaling pathway [IDA, IMP]
- cellular response to cation stress [IGI]
- cellular response to nitrogen starvation [IMP]
- mRNA export from nucleus in response to heat stress [IMP]
- mitotic cell cycle arrest in response to nitrogen starvation [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of transcription factor import into nucleus in response to oxidative stress [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP]
- regulation of DNA binding [IDA]
- regulation of cAMP-mediated signaling [IMP]
- regulation of cAMP-mediated signaling by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of cell shape involved in G1 to G0 transition [IMP]
- regulation of chromatin assembly [IMP]
- regulation of chromatin disassembly [IMP]
- regulation of histone acetylation [IMP]
- regulation of mRNA stability involved in cellular response to UV [IMP]
- regulation of meiotic cell cycle [IMP]
- regulation of reciprocal meiotic recombination [IMP]
- regulation of translation in response to nitrogen starvation [IDA]
- regulation of translation in response to osmotic stress [IDA, IMP]
- regulation of translation in response to oxidative stress [IDA, IMP]
- stress granule assembly [IMP]
- stress granule disassembly [IMP]
- stress-activated MAPK cascade [IMP]
Gene Ontology Molecular Function
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast.
Simultaneous inactivation of pyp1 and pyp2 PTPases in fission yeast leads to aberrant cell morphology and growth arrest. Spontaneous recessive mutations that bypass the requirement for pyp1 and pyp2 and reside in two complementation groups were isolated, sty1 and sty2. sty1- and sty2- mutant cells are substantially delayed in the timing of mitotic initiation. We have isolated the sty1 gene, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC25 STY1 | Dosage Growth Defect Dosage Growth Defect A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 2609088 | |
| CDC25 STY1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | PomBase | 882980 | |
| STY1 CDC25 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 797454 | |
| CDC25 STY1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | PomBase | - |