BAIT
MFHAS1
LRRC65, MASL1
malignant fibrous histiocytoma amplified sequence 1
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
LIMK1
LIMK, LIMK-1
LIM domain kinase 1
GO Process (11)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- Rho protein signal transduction [TAS]
- actin cytoskeleton organization [TAS]
- axon guidance [TAS]
- innate immune response [TAS]
- negative regulation of ubiquitin-protein transferase activity [IDA]
- nervous system development [TAS]
- positive regulation of actin filament bundle assembly [IDA]
- positive regulation of axon extension [ISS]
- protein phosphorylation [IDA, IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.
Signal transduction cascades governed by kinases and GTPases are a critical component of the command and control of cellular processes, with the precise outcome partly determined by direct protein-protein interactions (PPIs). Here, we use the human ROCO proteins as a model for investigating PPI signaling events-taking advantage of the unique dual kinase/GTPase activities and scaffolding properties of these multidomain proteins. ... [more]
Proteomics May. 01, 2018; 18(10);e1700444 [Pubmed: 29513927]
Throughput
- High Throughput
Additional Notes
- Significant hits in the protein microarray had a Z-score threshold of Z > 3.
Curated By
- BioGRID