BAIT
ESR2
ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
estrogen receptor 2 (ER beta)
GO Process (10)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- cell-cell signaling [TAS]
- extracellular negative regulation of signal transduction [NAS]
- gene expression [TAS]
- intracellular estrogen receptor signaling pathway [TAS]
- negative regulation of cell growth [NAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- regulation of transcription, DNA-templated [TAS]
- signal transduction [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [TAS]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [TAS]
- estrogen response element binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, NAS]
- protein binding [IPI]
- receptor antagonist activity [NAS]
- sequence-specific DNA binding transcription factor activity [TAS]
- steroid binding [ISS, TAS]
- steroid hormone receptor activity [TAS]
- transcription coactivator activity [TAS]
- DNA binding [TAS]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [TAS]
- estrogen response element binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, NAS]
- protein binding [IPI]
- receptor antagonist activity [NAS]
- sequence-specific DNA binding transcription factor activity [TAS]
- steroid binding [ISS, TAS]
- steroid hormone receptor activity [TAS]
- transcription coactivator activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
CYP1B1
CP1B, CYPIB1, GLC3A, P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1
GO Process (32)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- arachidonic acid metabolic process [IDA, TAS]
- blood vessel morphogenesis [ISS]
- cell adhesion [ISS]
- cellular response to hydrogen peroxide [ISS]
- cellular response to organic cyclic compound [IDA]
- collagen fibril organization [ISS]
- endothelial cell migration [ISS]
- epoxygenase P450 pathway [TAS]
- estrogen metabolic process [IDA]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISS]
- membrane lipid catabolic process [ISS]
- negative regulation of NF-kappaB transcription factor activity [ISS]
- negative regulation of cell adhesion mediated by integrin [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [ISS]
- nitric oxide biosynthetic process [ISS]
- omega-hydroxylase P450 pathway [TAS]
- oxidation-reduction process [TAS]
- positive regulation of JAK-STAT cascade [ISS]
- positive regulation of angiogenesis [ISS]
- positive regulation of apoptotic process [ISS]
- positive regulation vascular endothelial growth factor production [ISS]
- regulation of reactive oxygen species metabolic process [ISS]
- retinal blood vessel morphogenesis [ISS]
- retinal metabolic process [IDA]
- retinol metabolic process [IDA]
- small molecule metabolic process [TAS]
- steroid metabolic process [IDA]
- sterol metabolic process [TAS]
- trabecular meshwork development [ISS]
- visual perception [TAS]
- xenobiotic metabolic process [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells.
The nuclear receptor estrogen receptor 2 (ESR2, ERβ) modulates cancer cell proliferation and tumor growth, exerting an oncosuppressive role in breast cancer (BC). Interaction proteomics by tandem affinity purification coupled to mass spectrometry was previously applied in BC cells to identify proteins acting in concert with ERβ to control key cellular functions, including gene transcription, RNA splicing and post-transcriptional mRNA ... [more]
Sci Data Dec. 06, 2017; 5();180031 [Pubmed: 29509190]
Throughput
- High Throughput
Curated By
- BioGRID