BAIT
NOD2
ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1
nucleotide-binding oligomerization domain containing 2
GO Process (56)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- JNK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- activation of MAPK activity involved in innate immune response [ISS]
- cellular response to muramyl dipeptide [IDA]
- cytokine production involved in immune response [IMP]
- defense response [TAS]
- defense response to bacterium [IDA]
- detection of bacterium [IDA]
- detection of biotic stimulus [TAS]
- detection of muramyl dipeptide [IDA]
- innate immune response [IDA, NAS, TAS]
- intracellular signal transduction [IDA]
- maintenance of gastrointestinal epithelium [IMP]
- negative regulation of macrophage apoptotic process [ISS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of B cell activation [IDA]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA, TAS]
- positive regulation of Notch signaling pathway [ISS]
- positive regulation of dendritic cell antigen processing and presentation [ISS]
- positive regulation of epithelial cell proliferation [ISS]
- positive regulation of gamma-delta T cell activation [ISS]
- positive regulation of interleukin-1 beta production [IMP]
- positive regulation of interleukin-1 beta secretion [IDA]
- positive regulation of interleukin-10 production [ISS]
- positive regulation of interleukin-17 production [IMP]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- positive regulation of oxidoreductase activity [ISS]
- positive regulation of phosphatidylinositol 3-kinase activity [ISS]
- positive regulation of prostaglandin-E synthase activity [ISS]
- positive regulation of prostaglandin-endoperoxide synthase activity [ISS]
- positive regulation of stress-activated MAPK cascade [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor production [IDA, IMP]
- positive regulation of type 2 immune response [IMP]
- protein oligomerization [TAS]
- regulation of inflammatory response [IC]
- response to muramyl dipeptide [IDA]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CHMP4B
C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4
charged multivesicular body protein 4B
GO Process (12)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- endosomal transport [TAS]
- membrane organization [TAS]
- negative regulation of autophagic vacuole assembly [IMP]
- negative regulation of neuron death [IMP]
- positive regulation of viral release from host cell [IMP]
- posttranslational protein targeting to membrane [IMP]
- protein homooligomerization [IDA]
- regulation of viral process [IMP]
- ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [IMP]
- viral budding via host ESCRT complex [IGI]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.
NOD2 contributes to the innate immune response and to the homeostasis of the intestinal mucosa. In response to its bacterial ligand, NOD2 interacts with RICK and activates the NF-κB and MAPK pathways, inducing gene transcription and synthesis of proteins required to initiate a balanced immune response. Mutations in NOD2 have been associated with an increased risk of Crohn's Disease (CD), ... [more]
PLoS ONE Nov. 05, 2016; 11(11);e0165420 [Pubmed: 27812135]
Throughput
- High Throughput
Additional Notes
- two hybrid screen of colon library
Curated By
- BioGRID