SDCBP
Gene Ontology Biological Process
- actin cytoskeleton organization [NAS]
- axon guidance [TAS]
- intracellular signal transduction [NAS]
- positive regulation of JNK cascade [IC]
- positive regulation of exosomal secretion [IMP]
- positive regulation of extracellular vesicular exosome assembly [IMP]
- positive regulation of phosphorylation [IDA]
- protein targeting to membrane [NAS]
- substrate-dependent cell migration, cell extension [NAS]
- synaptic transmission [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ULK1
Gene Ontology Biological Process
- autophagic vacuole assembly [IBA]
- axon extension [IBA]
- cellular response to nutrient levels [ISS]
- neuron projection development [IMP]
- positive regulation of autophagy [ISS]
- positive regulation of macroautophagy [IMP]
- protein autophosphorylation [IDA]
- protein localization [IMP]
- protein phosphorylation [NAS]
- regulation of autophagy [IDA, IMP]
- response to starvation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ATG1/UKL1 signaling complex [IBA]
- ULK1-ATG13-FIP200 complex [IPI]
- autophagic vacuole [IDA]
- cytoplasm [NAS]
- cytosol [IDA]
- extrinsic component of autophagic vacuole membrane [IDA]
- extrinsic component of omegasome membrane [IDA]
- extrinsic component of pre-autophagosomal structure membrane [IDA]
- pre-autophagosomal structure membrane [IDA]
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Role of Unc51.1 and its binding partners in CNS axon outgrowth.
Previous studies showed that the serine/threonine kinase Unc51.1 is one of the earliest genes in neuronal differentiation and is required for granule cell axon formation. To examine the mechanism of Unc51.1 regulation of axon extension, we have identified two direct binding partners. The first, SynGAP, a negative regulator of Ras, is expressed within axons and growth cones of developing granule ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ULK1 SDCBP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID