SCN1B
Gene Ontology Biological Process
- axon guidance [ISS, TAS]
- cardiac conduction [ISS]
- cardiac muscle cell action potential involved in contraction [IMP]
- cardiac muscle contraction [IMP]
- corticospinal neuron axon guidance [ISS]
- locomotion [ISS]
- membrane depolarization [IDA]
- membrane depolarization during Purkinje myocyte cell action potential [IMP]
- membrane depolarization during cardiac muscle cell action potential [ISS]
- neuronal action potential propagation [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of sodium ion transport [IDA]
- regulation of atrial cardiac muscle cell membrane depolarization [IMP]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of sodium ion transmembrane transporter activity [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISS]
- sodium ion transmembrane transport [IDA, IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- sodium channel inhibitor activity [ISS]
- sodium channel regulator activity [IDA]
- voltage-gated sodium channel activity [IDA]
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential [IMP]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [IMP]
- sodium channel inhibitor activity [ISS]
- sodium channel regulator activity [IDA]
- voltage-gated sodium channel activity [IDA]
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential [IMP]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [IMP]
Gene Ontology Cellular Component
CNTN1
Gene Ontology Biological Process
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin.
Voltage-gated sodium channels are composed of a pore-forming alpha subunit and at least one auxiliary beta subunit. Both beta1 and beta2 are cell adhesion molecules that interact homophilically, resulting in ankyrin recruitment. In contrast, beta1, but not beta2, interacts heterophilically with contactin, resulting in increased levels of cell surface sodium channels. We took advantage of these results to investigate the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID