BAIT

PFKP

ATP-PFK, PFK-C, PFK-P, PFKF, RP11-298E9.2
phosphofructokinase, platelet
Homo sapiens
PREY

AKT3

MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2
v-akt murine thymoma viral oncogene homolog 3
GO Process (2)
GO Function (4)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis.

Lee JH, Liu R, Li J, Zhang C, Wang Y, Cai Q, Qian X, Xia Y, Zheng Y, Piao Y, Chen Q, de Groot JF, Jiang T, Lu Z

Phosphofructokinase 1 (PFK1) plays a critical role in glycolysis; however, its role and regulation in tumorigenesis are not well understood. Here, we demonstrate that PFK1 platelet isoform (PFKP) is the predominant PFK1 isoform in human glioblastoma cells and its expression correlates with total PFK activity. We show that PFKP is overexpressed in human glioblastoma specimens due to an increased stability, ... [more]

Nat Commun Dec. 16, 2016; 8(1);949 [Pubmed: 29038421]

Throughput

  • Low Throughput

Curated By

  • BioGRID