BAIT
PRPF40A
2810012K09Rik, FBP11, Fnbp11, Fnbp3, RP23-282A22.2
PRP40 pre-mRNA processing factor 40 homolog A (yeast)
GO Process (4)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
WASF3
Scar3, Wave3
WAS protein family, member 3
GO Process (5)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation.
WASP family proteins are involved in cortical actin cytoskeleton reorganization. Neural Wiskott-Aldrich syndrome protein (N-WASP), a ubiquitously expressed WASP homologous protein, directly binds with Cdc42, activating Arp2/3 complex. In this study, we show that N-WASP-dependent microspike formation is inhibited by formin binding protein 11 (FBP11). Endogenous FBP11 localizes with nuclear-speckles, and co-localization of N-WASP and FBP11 was observed when they ... [more]
Biochem. Biophys. Res. Commun. Jan. 16, 2004; 313(3);468-74 [Pubmed: 14697212]
Throughput
- Low Throughput
Curated By
- BioGRID