BAIT
PRPF40A
2810012K09Rik, FBP11, Fnbp11, Fnbp3, RP23-282A22.2
PRP40 pre-mRNA processing factor 40 homolog A (yeast)
GO Process (4)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
WASL
2900021I12Rik, 3110031I02Rik, N-WASP
Wiskott-Aldrich syndrome-like (human)
GO Process (14)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- actin nucleation [TAS]
- cell projection assembly [IMP]
- cellular protein complex localization [IMP]
- membrane budding [ISO]
- membrane invagination [ISO]
- membrane tubulation [ISO]
- positive regulation of clathrin-mediated endocytosis [ISO]
- positive regulation of filopodium assembly [ISO]
- regulation of protein localization [IMP]
- response to bacterium [IMP]
- spindle localization [IMP]
- vesicle organization [ISO]
- vesicle transport along actin filament [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation.
WASP family proteins are involved in cortical actin cytoskeleton reorganization. Neural Wiskott-Aldrich syndrome protein (N-WASP), a ubiquitously expressed WASP homologous protein, directly binds with Cdc42, activating Arp2/3 complex. In this study, we show that N-WASP-dependent microspike formation is inhibited by formin binding protein 11 (FBP11). Endogenous FBP11 localizes with nuclear-speckles, and co-localization of N-WASP and FBP11 was observed when they ... [more]
Biochem. Biophys. Res. Commun. Jan. 16, 2004; 313(3);468-74 [Pubmed: 14697212]
Throughput
- Low Throughput
Curated By
- BioGRID