BAIT
HAND2
DHAND2, Hed, Thing2, bHLHa26, dHand
heart and neural crest derivatives expressed 2
GO Process (18)
GO Function (10)
GO Component (3)
Gene Ontology Biological Process
- adult heart development [IEP]
- apoptotic process [ISS]
- cardiac neural crest cell development involved in outflow tract morphogenesis [ISS]
- heart development [NAS]
- heart looping [ISS]
- heart morphogenesis [ISS]
- in utero embryonic development [ISS]
- negative regulation of cardiac muscle cell apoptotic process [ISS]
- neural crest cell development [ISS]
- noradrenergic neuron differentiation [NAS]
- positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process [ISS]
- positive regulation of transcription regulatory region DNA binding [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of secondary heart field cardioblast proliferation [ISS]
- regulation of transcription, DNA-templated [ISS]
- thymus development [ISS]
Gene Ontology Molecular Function- AT DNA binding [IDA]
- E-box binding [IDA, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [ISS]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- transcription coactivator activity [ISS]
- transcription factor binding [ISS]
- transcription regulatory region DNA binding [ISS]
- AT DNA binding [IDA]
- E-box binding [IDA, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [ISS]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- transcription coactivator activity [ISS]
- transcription factor binding [ISS]
- transcription regulatory region DNA binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
PREY
PPP2R5D
B56D
protein phosphatase 2, regulatory subunit B', delta
GO Process (23)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- carbohydrate metabolic process [TAS]
- dephosphorylation [TAS]
- energy reserve metabolic process [TAS]
- glucose metabolic process [TAS]
- glycolytic process [TAS]
- innate immune response [TAS]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of catalytic activity [TAS]
- small molecule metabolic process [TAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.
The bHLH factors HAND1 and HAND2 are required for heart, vascular, neuronal, limb, and extraembryonic development. Unlike most bHLH proteins, HAND factors exhibit promiscuous dimerization properties. We report that phosphorylation/dephosphorylation via PKA, PKC, and a specific heterotrimeric protein phosphatase 2A (PP2A) modulates HAND function. The PP2A targeting-subunit B56delta specifically interacts with HAND1 and -2, but not other bHLH proteins. PKA ... [more]
Mol. Cell Nov. 01, 2003; 12(5);1225-37 [Pubmed: 14636580]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPP2R5D HAND2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID