AGR2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AKR1C2
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- cellular response to jasmonic acid stimulus [IDA]
- cellular response to prostaglandin D stimulus [IDA]
- daunorubicin metabolic process [IMP]
- digestion [IDA]
- doxorubicin metabolic process [IMP]
- epithelial cell differentiation [IEP]
- oxidation-reduction process [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of protein kinase B signaling [IDA]
- progesterone metabolic process [IDA]
- prostaglandin metabolic process [IDA]
- steroid metabolic process [IDA]
Gene Ontology Molecular Function- alditol:NADP+ 1-oxidoreductase activity [IDA]
- bile acid binding [IDA]
- carboxylic acid binding [IDA]
- ketosteroid monooxygenase activity [IDA]
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [IDA]
- phenanthrene 9,10-monooxygenase activity [IDA]
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [IDA]
- alditol:NADP+ 1-oxidoreductase activity [IDA]
- bile acid binding [IDA]
- carboxylic acid binding [IDA]
- ketosteroid monooxygenase activity [IDA]
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [IDA]
- phenanthrene 9,10-monooxygenase activity [IDA]
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.
Anterior gradient 2 (AGR2) is a member of the protein disulfide isomerase (PDI) family, which plays a role in the regulation of protein homeostasis and the unfolded protein response pathway (UPR). AGR2 has also been characterized as a proto-oncogene and a potential cancer biomarker. Cellular localization of AGR2 is emerging as a key component for understanding the role of AGR2 ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
AGR2 AKR1C2 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID