BAIT
BAIAP2
Irsp53
BAI1-associated protein 2
GO Process (8)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- actin crosslink formation [ISO, ISS]
- actin filament bundle assembly [ISO, ISS]
- dendrite development [ISO]
- positive regulation of dendritic spine morphogenesis [IMP]
- regulation of actin cytoskeleton organization [ISO, ISS]
- regulation of cell shape [ISO, ISS]
- regulation of synaptic plasticity [ISO]
- response to bacterium [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
DLG3
Dlgh3
discs, large homolog 3 (Drosophila)
GO Process (3)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- dendritic shaft [IDA]
- extracellular space [ISO]
- growth cone [IDA]
- neuronal cell body [IDA]
- plasma membrane [ISO]
- postsynaptic density [IDA, TAS]
- synapse [IDA]
- tight junction [ISO]
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
MALS is a binding partner of IRSp53 at cell-cell contacts.
Insulin receptor substrate p53 (IRSp53) is a key player in cytoskeletal dynamics, interacting with the actin modulators WAVE2 and Mena. Here, we identified a PDZ protein, MALS, as an IRSp53-interacting protein using a yeast two-hybrid screen. A pull-down assay showed that IRSp53 and MALS interact through the PDZ domain of MALS and the C-terminal PDZ-binding sequence of IRSp53. Their interaction ... [more]
FEBS Lett. Nov. 06, 2003; 554(1);30-4 [Pubmed: 14596909]
Throughput
- Low Throughput
Curated By
- BioGRID