BAIT
BAIAP2
Irsp53
BAI1-associated protein 2
GO Process (8)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- actin crosslink formation [ISO, ISS]
- actin filament bundle assembly [ISO, ISS]
- dendrite development [ISO]
- positive regulation of dendritic spine morphogenesis [IMP]
- regulation of actin cytoskeleton organization [ISO, ISS]
- regulation of cell shape [ISO, ISS]
- regulation of synaptic plasticity [ISO]
- response to bacterium [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
MAGI2
Acvrinp1, Acvrip1, S-SCAM
membrane associated guanylate kinase, WW and PDZ domain containing 2
GO Process (17)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- SMAD protein signal transduction [ISO, ISS]
- cellular response to nerve growth factor stimulus [IDA]
- cytoplasmic transport [IMP]
- glomerular filtration [IC]
- glomerular visceral epithelial cell development [IEP]
- mitotic cell cycle arrest [IDA]
- negative regulation of activin receptor signaling pathway [ISO, ISS]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of protein kinase B signaling [ISO, ISS]
- nerve growth factor signaling pathway [IDA]
- positive regulation of neuron projection development [IMP]
- positive regulation of phosphoprotein phosphatase activity [ISO, ISS]
- positive regulation of receptor internalization [ISO, ISS]
- protein heterooligomerization [IDA]
- receptor clustering [IDA]
- signal transduction [ISO]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- SMAD binding [ISO, ISS]
- beta-1 adrenergic receptor binding [ISO, ISS]
- phosphatase binding [ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- receptor signaling complex scaffold activity [ISO, ISS]
- signal transducer activity [ISO, ISS]
- type II activin receptor binding [ISO, ISS]
- PDZ domain binding [IPI]
- SMAD binding [ISO, ISS]
- beta-1 adrenergic receptor binding [ISO, ISS]
- phosphatase binding [ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- receptor signaling complex scaffold activity [ISO, ISS]
- signal transducer activity [ISO, ISS]
- type II activin receptor binding [ISO, ISS]
Gene Ontology Cellular Component
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
MALS is a binding partner of IRSp53 at cell-cell contacts.
Insulin receptor substrate p53 (IRSp53) is a key player in cytoskeletal dynamics, interacting with the actin modulators WAVE2 and Mena. Here, we identified a PDZ protein, MALS, as an IRSp53-interacting protein using a yeast two-hybrid screen. A pull-down assay showed that IRSp53 and MALS interact through the PDZ domain of MALS and the C-terminal PDZ-binding sequence of IRSp53. Their interaction ... [more]
FEBS Lett. Nov. 06, 2003; 554(1);30-4 [Pubmed: 14596909]
Throughput
- Low Throughput
Curated By
- BioGRID