BMPR2
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP, ISS, TAS]
- activin receptor signaling pathway [TAS]
- anterior/posterior pattern specification [ISS]
- artery development [ISS]
- blood vessel remodeling [ISS]
- cellular response to starvation [IEP]
- chondrocyte development [IMP]
- lung alveolus development [ISS]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [ISS]
- mesoderm formation [ISS]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of chondrocyte proliferation [IMP]
- negative regulation of systemic arterial blood pressure [IMP]
- negative regulation of vasoconstriction [ISS]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of bone mineralization [IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of epithelial cell migration [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- regulation of cell proliferation [IMP]
- regulation of lung blood pressure [IMP, ISS]
- retina vasculature development in camera-type eye [ISS]
- transcription from RNA polymerase II promoter [IMP]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IDA]
- vascular endothelial growth factor receptor signaling pathway [ISS]
- venous blood vessel development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KIT
Gene Ontology Biological Process
- Fc receptor signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- Kit signaling pathway [IDA]
- T cell differentiation [ISS]
- actin cytoskeleton reorganization [IDA]
- activation of MAPK activity [IDA]
- cell chemotaxis [IDA]
- cytokine-mediated signaling pathway [IDA]
- dendritic cell cytokine production [ISS]
- detection of mechanical stimulus involved in sensory perception of sound [ISS]
- digestive tract development [ISS]
- embryonic hemopoiesis [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- erythrocyte differentiation [ISS]
- erythropoietin-mediated signaling pathway [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- hemopoiesis [TAS]
- immature B cell differentiation [ISS]
- inflammatory response [ISS]
- innate immune response [TAS]
- lamellipodium assembly [ISS]
- male gonad development [IEP]
- mast cell chemotaxis [IDA]
- mast cell cytokine production [IDA]
- mast cell degranulation [IMP]
- mast cell differentiation [ISS, TAS]
- mast cell proliferation [TAS]
- megakaryocyte development [ISS]
- melanocyte adhesion [ISS]
- melanocyte differentiation [ISS, TAS]
- melanocyte migration [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- ovarian follicle development [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- pigmentation [ISS]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [TAS]
- positive regulation of phosphatidylinositol 3-kinase signaling [TAS]
- positive regulation of phospholipase C activity [TAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IMP]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IMP]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IMP]
- protein autophosphorylation [IDA]
- regulation of cell proliferation [TAS]
- regulation of cell shape [ISS]
- signal transduction [TAS]
- signal transduction by phosphorylation [TAS]
- spermatogenesis [ISS, TAS]
- stem cell differentiation [ISS]
- stem cell maintenance [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Interaction and functional cooperation between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine kinase stem cell factor receptor.
Transmembrane receptors with intrinsic serine/threonine or tyrosine kinase domains regulate vital functions of cells in multicellular eukaryotes, e.g., differentiation, apoptosis, and proliferation. Here, we show that bone morphogenetic protein type II receptor (BMPR-II) which has a serine/threonine kinase domain, and stem cell factor receptor (c-kit) which contains a tyrosine kinase domain form a complex in vitro and in vivo; the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BMPR2 KIT | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| BMPR2 KIT | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| KIT BMPR2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID