IGF1
Gene Ontology Biological Process
- DNA replication [TAS]
- Ras protein signal transduction [TAS]
- blood coagulation [TAS]
- bone mineralization involved in bone maturation [IDA]
- cell activation [IDA]
- cellular component movement [TAS]
- cellular protein metabolic process [TAS]
- glycolate metabolic process [TAS]
- muscle hypertrophy [IMP]
- muscle organ development [TAS]
- myoblast differentiation [IDA]
- myoblast proliferation [IDA]
- myotube cell development [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of oocyte development [IMP]
- negative regulation of release of cytochrome c from mitochondria [ISS]
- negative regulation of smooth muscle cell apoptotic process [IDA]
- phosphatidylinositol-mediated signaling [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of DNA binding [IDA]
- positive regulation of DNA replication [IDA, ISS]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Ras protein signal transduction [IDA]
- positive regulation of activated T cell proliferation [IDA]
- positive regulation of calcineurin-NFAT signaling cascade [IDA]
- positive regulation of cardiac muscle hypertrophy [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of glucose import [IDA]
- positive regulation of glycogen biosynthetic process [IDA]
- positive regulation of glycolytic process [IDA]
- positive regulation of insulin-like growth factor receptor signaling pathway [IDA]
- positive regulation of mitosis [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein import into nucleus, translocation [IDA]
- positive regulation of smooth muscle cell migration [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- proteoglycan biosynthetic process [IDA]
- regulation of gene expression [IMP]
- regulation of multicellular organism growth [IEP]
- signal transduction [TAS]
- skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [IDA]
- skeletal system development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IGFBP7
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Proteolytic processing of IGFBP-related protein-1 (TAF/angiomodulin/mac25) modulates its biological activity.
Insulin-like growth factor (IGF) binding protein-related protein-1 (IGFBP-rP1) was previously identified as tumor-derived adhesion factor (TAF) secreted from human bladder carcinoma cells. It exhibits growth-stimulatory activity in synergy with insulin or IGFs. In the present study, we found that IGFBP-rP1 was proteolytically cleaved to a two-chain form. The cleavage sequence suggested that a trypsin-like serine proteinase may be responsible for ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IGFBP7 IGF1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID