BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
MAD2L1
HSMAD2, MAD2
MAD2 mitotic arrest deficient-like 1 (yeast)
GO Process (11)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic cell cycle checkpoint [IDA, IGI]
- mitotic spindle assembly checkpoint [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of mitotic anaphase-promoting complex activity [IDA]
- negative regulation of mitotic cell cycle [IMP]
- negative regulation of protein catabolic process [IDA]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of mitotic cell cycle spindle assembly checkpoint [IMP]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer.
Overexpressed in colon carcinoma-1 (OCC-1) is one of the earliest annotated long noncoding RNAs (lncRNAs) in colorectal cancer (CRC); however, its function remains largely unknown. Here, we revealed that OCC-1 plays a tumor suppressive role in CRC. OCC-1 knockdown by RNA interference promotes cell growth both in vitro and in vivo, which is largely due to its ability to inhibit ... [more]
Nucleic Acids Res. Jun. 20, 2018; 46(11);5809-5821 [Pubmed: 29931370]
Throughput
- Low Throughput
Additional Notes
- HuR protein IP (immunoprecipitation) pulled down RNAs of the indicated hit proteins
Curated By
- BioGRID