BAIT
SOCS1
CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
suppressor of cytokine signaling 1
GO Process (12)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- cytokine-mediated signaling pathway [IBA, ISS, TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of JAK-STAT cascade [IBA, ISS, NAS]
- negative regulation of insulin receptor signaling pathway [IBA, ISS]
- negative regulation of protein kinase activity [TAS]
- negative regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of protein phosphorylation [ISS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
BSG
5F7, CD147, EMMPRIN, M6, OK, TCSF, UNQ6505/PRO21383
basigin (Ok blood group)
GO Process (9)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell surface receptor signaling pathway [TAS]
- cellular metabolic process [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- leukocyte migration [TAS]
- protein targeting to plasma membrane [ISS]
- pyruvate metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia.
Downregulation of suppressor of cytokine signalling-1 (SOCS1) is one of the vital reasons for JAK1-STAT3 pathway activation in acute myeloid leukaemia (AML). CUE domain-containing 2 (CUEDC2) was a novel interacting partner of SOCS1 and a positive correlation between the expression of CUEDC2 and SOCS1 was confirmed in primary AML cells and AML cell lines without SOCS1 promoter methylation. We aimed ... [more]
Cell Death Dis Jul. 10, 2018; 9(7);774 [Pubmed: 29991678]
Throughput
- High Throughput
Curated By
- BioGRID