BAIT
SOCS1
CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
suppressor of cytokine signaling 1
GO Process (12)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- cytokine-mediated signaling pathway [IBA, ISS, TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of JAK-STAT cascade [IBA, ISS, NAS]
- negative regulation of insulin receptor signaling pathway [IBA, ISS]
- negative regulation of protein kinase activity [TAS]
- negative regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of protein phosphorylation [ISS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
SSBP1
Mt-SSB, SOSS-B1, SSBP, mtSSB
single-stranded DNA binding protein 1, mitochondrial
GO Process (1)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia.
Downregulation of suppressor of cytokine signalling-1 (SOCS1) is one of the vital reasons for JAK1-STAT3 pathway activation in acute myeloid leukaemia (AML). CUE domain-containing 2 (CUEDC2) was a novel interacting partner of SOCS1 and a positive correlation between the expression of CUEDC2 and SOCS1 was confirmed in primary AML cells and AML cell lines without SOCS1 promoter methylation. We aimed ... [more]
Cell Death Dis Jul. 10, 2018; 9(7);774 [Pubmed: 29991678]
Throughput
- High Throughput
Curated By
- BioGRID