BAIT
ACVRL1
ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I
activin A receptor type II-like 1
GO Process (37)
GO Function (11)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [IMP]
- activin receptor signaling pathway [IDA]
- angiogenesis [IMP]
- artery development [ISS]
- blood circulation [IMP]
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis [TAS]
- blood vessel maturation [TAS]
- blood vessel remodeling [ISS]
- cellular response to BMP stimulus [IMP]
- cellular response to transforming growth factor beta stimulus [IDA]
- endothelial tube morphogenesis [IMP]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [IMP]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of blood vessel endothelial cell migration [IMP]
- negative regulation of cell adhesion [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of endothelial cell migration [IDA]
- negative regulation of focal adhesion assembly [IMP]
- positive regulation of BMP signaling pathway [IDA]
- positive regulation of chondrocyte differentiation [TAS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- regulation of DNA replication [TAS]
- regulation of blood pressure [IMP]
- regulation of blood vessel endothelial cell migration [TAS]
- regulation of endothelial cell proliferation [TAS]
- regulation of transcription, DNA-templated [IMP]
- retina vasculature development in camera-type eye [ISS]
- signal transduction [IDA]
- transforming growth factor beta receptor signaling pathway [IDA]
- venous blood vessel development [ISS]
- wound healing, spreading of epidermal cells [IMP]
Gene Ontology Molecular Function- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
CDK12
CRK7, CRKR, CRKRS, RP11-390P24.1
cyclin-dependent kinase 12
GO Process (4)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.
Identification of effective combination therapies is critical to address the emergence of drug-resistant cancers, but direct screening of all possible drug combinations is infeasible. Here we introduce a CRISPR-based double knockout (CDKO) system that improves the efficiency of combinatorial genetic screening using an effective strategy for cloning and sequencing paired single guide RNA (sgRNA) libraries and a robust statistical scoring ... [more]
Nat. Biotechnol. Mar. 20, 2017; 0(); [Pubmed: 28319085]
Quantitative Score
- -2.995 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
Additional Notes
- CRISPR GI screen
- Cell Line:K562 (EFO:0002067)
- Experimental Setup:Timecourse
- GIST: A-phenotypic negative genetic interaction
- Library:Drug Target-CDKO CRISPRn library
- Significance Threshold: q-value<0.05
Curated By
- BioGRID