BAIT
EPHB2
CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5
EPH receptor B2
GO Process (16)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- angiogenesis [ISS]
- axon guidance [ISS, TAS]
- axonal fasciculation [ISS]
- commissural neuron axon guidance [ISS]
- corpus callosum development [ISS]
- dendritic spine development [ISS]
- dendritic spine morphogenesis [ISS]
- ephrin receptor signaling pathway [ISS]
- inner ear morphogenesis [ISS]
- nervous system development [TAS]
- palate development [ISS]
- peptidyl-tyrosine phosphorylation [ISS]
- phosphorylation [ISS]
- positive regulation of synapse assembly [ISS]
- regulation of body fluid levels [ISS]
- urogenital system development [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
GPX1
GPXD, GSHPX1
glutathione peroxidase 1
GO Process (21)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- UV protection [IMP]
- arachidonic acid metabolic process [TAS]
- cell redox homeostasis [IDA]
- cellular response to oxidative stress [NAS]
- glutathione metabolic process [IDA]
- heart contraction [IMP]
- hydrogen peroxide catabolic process [IDA]
- lipoxygenase pathway [TAS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of release of cytochrome c from mitochondria [IMP]
- nucleobase-containing small molecule metabolic process [TAS]
- positive regulation of fibril organization [ISS]
- purine nucleobase metabolic process [TAS]
- purine nucleotide catabolic process [TAS]
- regulation of gene expression, epigenetic [IDA]
- regulation of mammary gland epithelial cell proliferation [IMP]
- regulation of proteasomal protein catabolic process [IDA]
- response to hydrogen peroxide [IMP]
- response to selenium ion [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.
Identification of effective combination therapies is critical to address the emergence of drug-resistant cancers, but direct screening of all possible drug combinations is infeasible. Here we introduce a CRISPR-based double knockout (CDKO) system that improves the efficiency of combinatorial genetic screening using an effective strategy for cloning and sequencing paired single guide RNA (sgRNA) libraries and a robust statistical scoring ... [more]
Nat. Biotechnol. Mar. 20, 2017; 0(); [Pubmed: 28319085]
Quantitative Score
- -2.896 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
Additional Notes
- CRISPR GI screen
- Cell Line:K562 (EFO:0002067)
- Experimental Setup:Timecourse
- GIST: A-phenotypic negative genetic interaction
- Library:Drug Target-CDKO CRISPRn library
- Significance Threshold: q-value<0.05
Curated By
- BioGRID