BAIT
ARNT
HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2
aryl hydrocarbon receptor nuclear translocator
GO Process (13)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- cellular response to hypoxia [TAS]
- mRNA transcription from RNA polymerase II promoter [IC]
- positive regulation of endothelial cell proliferation [IC]
- positive regulation of erythrocyte differentiation [IC]
- positive regulation of glycolytic process [IC]
- positive regulation of hormone biosynthetic process [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IC]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- response to hypoxia [IDA]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor binding [IPI]
- enhancer binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor binding [IPI]
- enhancer binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
CYP1B1
CP1B, CYPIB1, GLC3A, P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1
GO Process (32)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- arachidonic acid metabolic process [IDA, TAS]
- blood vessel morphogenesis [ISS]
- cell adhesion [ISS]
- cellular response to hydrogen peroxide [ISS]
- cellular response to organic cyclic compound [IDA]
- collagen fibril organization [ISS]
- endothelial cell migration [ISS]
- epoxygenase P450 pathway [TAS]
- estrogen metabolic process [IDA]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISS]
- membrane lipid catabolic process [ISS]
- negative regulation of NF-kappaB transcription factor activity [ISS]
- negative regulation of cell adhesion mediated by integrin [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [ISS]
- nitric oxide biosynthetic process [ISS]
- omega-hydroxylase P450 pathway [TAS]
- oxidation-reduction process [TAS]
- positive regulation of JAK-STAT cascade [ISS]
- positive regulation of angiogenesis [ISS]
- positive regulation of apoptotic process [ISS]
- positive regulation vascular endothelial growth factor production [ISS]
- regulation of reactive oxygen species metabolic process [ISS]
- retinal blood vessel morphogenesis [ISS]
- retinal metabolic process [IDA]
- retinol metabolic process [IDA]
- small molecule metabolic process [TAS]
- steroid metabolic process [IDA]
- sterol metabolic process [TAS]
- trabecular meshwork development [ISS]
- visual perception [TAS]
- xenobiotic metabolic process [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Aryl hydrocarbon receptor (AHR) regulation of L-Type Amino Acid Transporter 1 (LAT-1) expression in MCF-7 and MDA-MB-231 breast cancer cells.
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is regulated by environmental toxicants that function as AHR agonists such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). L-Type Amino Acid Transporter 1 (LAT1) is a leucine transporter that is overexpressed in cancer. The regulation of LAT1 by AHR in MCF-7 and MDA-MB-231 breast cancer cells (BCCs) was investigated in this report. Ingenuity ... [more]
Biochem. Pharmacol. Apr. 15, 2016; 106();94-103 [Pubmed: 26944194]
Throughput
- Low Throughput
Additional Notes
- ChIP
Curated By
- BioGRID