An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.

Publication

Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation.

Miralem T, Lerner-Marmarosh N, Gibbs PE, Jenkins JL, Heimiller C, Maines MD

Biliverdin reductase A (BVR) and Akt isozymes have overlapping pleiotropic functions in the insulin/PI3K/MAPK pathway. Human BVR (hBVR) also reduces the hemeoxygenase activity product biliverdin to bilirubin and is directly activated by insulin receptor kinase (IRK). Akt isoenzymes (Akt1-3) are downstream of IRK and are activated by phosphatidylinositol-dependent kinase 1 (PDK1) phosphorylating T(308) before S(473) autophosphorylation. Akt (RxRxxSF) and PDK1 ... [more]

FASEB J. Dec. 01, 2015; 30(8);2926-44 [Pubmed: 27166089]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
BLVRA AKT2	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Miralem T (2016)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

AKT2

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATP binding [IDA]kinase activity [TAS]protein binding [IPI]protein serine/threonine kinase activity [IDA, TAS]

Gene Ontology Cellular Component

BLVRA