BAIT
RPS6KA1
HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk, RP11-492M19.2
ribosomal protein S6 kinase, 90kDa, polypeptide 1
GO Process (26)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- axon guidance [TAS]
- innate immune response [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of cell differentiation [TAS]
- positive regulation of cell growth [TAS]
- positive regulation of hepatic stellate cell activation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of DNA-templated transcription in response to stress [TAS]
- regulation of translation in response to stress [TAS]
- signal transduction [TAS]
- stress-activated MAPK cascade [TAS]
- synaptic transmission [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
SHANK3
DEL22q13.3, PROSAP2, PSAP2, SCZD15, SPANK-2
SH3 and multiple ankyrin repeat domains 3
GO Process (27)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- MAPK cascade [ISS]
- N-methyl-D-aspartate receptor clustering [ISS]
- adult behavior [IMP]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISS]
- brain morphogenesis [ISS]
- dendritic spine morphogenesis [ISS]
- guanylate kinase-associated protein clustering [ISS]
- learning [IMP, ISS]
- memory [ISS]
- negative regulation of actin filament bundle assembly [ISS]
- negative regulation of cell volume [ISS]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- positive regulation of dendritic spine development [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of glutamate receptor signaling pathway [ISS]
- positive regulation of long-term neuronal synaptic plasticity [ISS]
- positive regulation of synapse structural plasticity [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- postsynaptic density assembly [ISS]
- regulation of dendritic spine morphogenesis [ISS]
- regulation of long term synaptic depression [ISS]
- regulation of long-term synaptic potentiation [ISS]
- social behavior [IMP, ISS]
- striatal medium spiny neuron differentiation [ISS]
- synapse assembly [ISS]
- vocal learning [IMP]
- vocalization behavior [IMP, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.
Phosphorylation of short linear peptide motifs is a widespread process for the dynamic regulation of protein-protein interactions. However, the global impact of phosphorylation events on the protein-protein interactome is rarely addressed. The disordered C-terminal tail of ribosomal S6 kinase 1 (RSK1) binds to PDZ domain-containing scaffold proteins, and it harbors a phosphorylatable PDZ-binding motif (PBM) responsive to epidermal growth factor ... [more]
J. Mol. Biol. Mar. 15, 2019; 431(6);1234-1249 [Pubmed: 30726710]
Throughput
- Low Throughput
Curated By
- BioGRID