KDM1A
Gene Ontology Biological Process
- cell proliferation [IMP]
- chromatin organization involved in regulation of transcription [IC]
- granulocyte differentiation [IMP]
- guanine metabolic process [ISO]
- histone H3-K4 demethylation [ISO]
- histone H3-K9 demethylation [IMP, ISO]
- in utero embryonic development [IMP]
- muscle cell development [IMP]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- negative regulation of histone H3-K4 methylation [IMP]
- negative regulation of histone H3-K9 methylation [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- oxidation-reduction process [ISO]
- pituitary gland development [IMP]
- positive regulation of cell size [ISO]
- positive regulation of chromatin binding [ISO]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of hormone biosynthetic process [IMP]
- positive regulation of megakaryocyte differentiation [IMP]
- positive regulation of neural precursor cell proliferation [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of stem cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- protein demethylation [ISO]
- regulation of primitive erythrocyte differentiation [IMP]
- regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- MRF binding [IPI, ISO]
- RNA polymerase II transcription factor binding [IPI]
- androgen receptor binding [ISO]
- chromatin binding [ISO]
- demethylase activity [ISO]
- enzyme binding [IPI, ISO]
- flavin adenine dinucleotide binding [ISO]
- histone demethylase activity [ISO]
- histone demethylase activity (H3-K4 specific) [ISO]
- histone demethylase activity (H3-K9 specific) [ISO]
- histone demethylase activity (H3-dimethyl-K4 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- oxidoreductase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IDA]
- MRF binding [IPI, ISO]
- RNA polymerase II transcription factor binding [IPI]
- androgen receptor binding [ISO]
- chromatin binding [ISO]
- demethylase activity [ISO]
- enzyme binding [IPI, ISO]
- flavin adenine dinucleotide binding [ISO]
- histone demethylase activity [ISO]
- histone demethylase activity (H3-K4 specific) [ISO]
- histone demethylase activity (H3-K9 specific) [ISO]
- histone demethylase activity (H3-dimethyl-K4 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- oxidoreductase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
KDM5A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.
Esrrb (oestrogen-related receptor beta) is a transcription factor implicated in embryonic stem (ES) cell self-renewal, yet its knockout causes intrauterine lethality due to defects in trophoblast development. Here we show that in trophoblast stem (TS) cells, Esrrb is a downstream target of fibroblast growth factor (Fgf) signalling and is critical to drive TS cell self-renewal. In contrast to its occupancy ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KDM1A KDM5A | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 3530280 |
Curated By
- BioGRID