KDM1A
Gene Ontology Biological Process
- cell proliferation [IMP]
- chromatin organization involved in regulation of transcription [IC]
- granulocyte differentiation [IMP]
- guanine metabolic process [ISO]
- histone H3-K4 demethylation [ISO]
- histone H3-K9 demethylation [IMP, ISO]
- in utero embryonic development [IMP]
- muscle cell development [IMP]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- negative regulation of histone H3-K4 methylation [IMP]
- negative regulation of histone H3-K9 methylation [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- oxidation-reduction process [ISO]
- pituitary gland development [IMP]
- positive regulation of cell size [ISO]
- positive regulation of chromatin binding [ISO]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of hormone biosynthetic process [IMP]
- positive regulation of megakaryocyte differentiation [IMP]
- positive regulation of neural precursor cell proliferation [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of stem cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- protein demethylation [ISO]
- regulation of primitive erythrocyte differentiation [IMP]
- regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- MRF binding [IPI, ISO]
- RNA polymerase II transcription factor binding [IPI]
- androgen receptor binding [ISO]
- chromatin binding [ISO]
- demethylase activity [ISO]
- enzyme binding [IPI, ISO]
- flavin adenine dinucleotide binding [ISO]
- histone demethylase activity [ISO]
- histone demethylase activity (H3-K4 specific) [ISO]
- histone demethylase activity (H3-K9 specific) [ISO]
- histone demethylase activity (H3-dimethyl-K4 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- oxidoreductase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IDA]
- MRF binding [IPI, ISO]
- RNA polymerase II transcription factor binding [IPI]
- androgen receptor binding [ISO]
- chromatin binding [ISO]
- demethylase activity [ISO]
- enzyme binding [IPI, ISO]
- flavin adenine dinucleotide binding [ISO]
- histone demethylase activity [ISO]
- histone demethylase activity (H3-K4 specific) [ISO]
- histone demethylase activity (H3-K9 specific) [ISO]
- histone demethylase activity (H3-dimethyl-K4 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- oxidoreductase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
KDM5A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.
Lysine specific demethylase 1 (LSD1) regulates gene expression as part of the CoREST complex, along with co-repressor of REST (CoREST) and histone deacetylase 1 (HDAC1). CoREST is recruited to specific genomic loci by core components and numerous transient interactions with chromatin-associated factors and transcription factors. We hypothesise that many of these weaker and transient associations may be difficult to identify ... [more]
Throughput
- High Throughput
Additional Notes
- (66 hour time point)
- BioID
- LSD1 interaction in mouse embryonic stem cells treated with retinoic acid (RA) to stimulate ES cell differentiation.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KDM1A KDM5A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID